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Chromatographic Separation

Mitsubishi Chemical Aqua Solutions Co., Ltd. has been developing a new separation and purification process using chromatographic separation technology originally developed by Mitsubishi Chemical Co. group, combined with experienced distinguished application technology for ion exchange resins.
In 1977 our technology was originally established as the continuous separation process between fructose and glucose in the high fructose corn syrup(HFCS) production process, then became an essential process in this industry, and more than 100 plants have been built and operated in the world.
Furthermore, we have been seeking to improve and spread this technology for new field such as separation and purification of sugar, oligosaccharide and other foodstuffs or pharmaceuticals.

Various chromatography separation system

Various chromatography separation systems have been developed so far and realized the separation of the component which could not be separated by the conventional chemical engineering unit operation.

Single Bed Separation
  This system is established by the scale up of the chromatography analysis method. The system is very simple and economical, however, higher separation performance of the purity and the recovery ratio can not be expected.

Simulated Moving Bed
  This system obtains two fractions from the solution containing two or more components by the difference of their moving rate through the separation material. It normally ,consists of 8 - 16 numbers of beds and can obtain good product purity and high separation efficiency,however, the system configuration and control becomes complicated and construction cost will be higher due to many numbers of the beds.

Improved Simulated Moving Bed
  This system requires less numbers of beds, basically 4beds, to keep higher separation performance than the conventional simulated moving bed system.
Therefore, the initial cost will be reduced and the reliability of system control and operation can be increased with this simple system configuration.
The pressure loss through the resin beds is reduced almost half of the conventional system. As a result, fine sized resin with higher separation performance can be selected.
The well-designed distribution and collection system which allows uniform flow through the bed, is essential to get perfect separation. It can be realized in the large sized column up to 5 meters in diameter.

  In conventional SMB systems, the feed, extraction and circulation are carried out continuousely in each step.
As the extraction range in this system corresponds to one bed which divides the concentration distribution profile by the number of the beds as illustrated in Fig.4, many beds are required to get high sepsration performance.

  In ISMB system, the feed-extraction step and circulation step are operated separately.
The extraction range can be determined by the ratio of circulation step and feed/extraction step. In our ISMB system, we can reduce extraction range to get higher performance with less numbers of beds.

Multi components separation
  "New MCI method" is an epoch-making process which provides efficient separation for three or more components by simple system.This system has the flexibility on the separation pattern, so that it can be used for many applications in the field of sugar, foodstuffs and pharmaceutical industry.

< Separation sample-1 >
F/G separation by ISMB ( Recovery ratio 95.0% )
Components Feed(%) F fraction(%) G fraction(%)
Fructose 43.0 94.0 3.8
Glucose 52.0 4.0 88.9
Oligosaccharide 5.0 2.0 7.3
Solids content 60.0 38.0 28.0

F/G separation by ISMB ( Recovery ratio 91.0% )
Components Feed(%) F fraction(%) G fraction(%)
Fructose 44.0 97.0 6.7
Glucose 51.2 1.0 86.5
Oligosaccharide 4.8 2.0 6.8
Solids content 60.0 36.0 25.4

< Separation sample-2>
Multi components separation from oligosaccharide by new MCI method
Components Feed(%) Each fraction(%) Recovery
ratio (%)
DP3 26.0 - 15.0 84.5 65.0
DP2 55.0 6.7 83.0 15.0 92.0
DP1 19.0 93.2 2.0 0.5 98.0
Solid content 60.0 7.0 24.0 6.0  

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